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99 lines
2.3 KiB
99 lines
2.3 KiB
2 years ago
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: BK-type Purkinje calcium-activated potassium current
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: Created 8/19/02 - nwg
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NEURON {
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THREADSAFE
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SUFFIX bkpkj
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USEION k READ ek WRITE ik
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USEION ca READ cai
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RANGE gbar, ik, gbkpkj
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GLOBAL minf, mtau, hinf, htau, zinf, ztau
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GLOBAL m_vh, m_k, mtau_y0, mtau_vh1, mtau_vh2, mtau_k1, mtau_k2
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GLOBAL z_coef, ztau
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GLOBAL h_y0, h_vh, h_k, htau_y0, htau_vh1, htau_vh2, htau_k1, htau_k2
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}
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UNITS {
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(mV) = (millivolt)
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(mA) = (milliamp)
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(mM) = (milli/liter)
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}
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PARAMETER {
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v (mV)
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gbar = 0.007 (mho/cm2)
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m1 (ms)
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m_vh = -28.9 (mV)
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m_k = 6.2 (mV)
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mtau_y0 = 0.505 (ms) : 0.000505 (s)
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mtau_vh1 = -33.3 (mV)
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mtau_k1 = -10 (mV)
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mtau_vh2 = 86.4 (mV)
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mtau_k2 = 10.1 (mV)
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z_coef = 0.001 (mM)
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ztau = 1 (ms)
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h_y0 = 0.085
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h_vh = -32 (mV)
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h_k = 5.8 (mV)
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htau_y0 = 1.9 (ms) : 0.0019 (s)
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htau_vh1 = -54.2 (mV)
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htau_k1 = -12.9 (mV)
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htau_vh2 = 48.5 (mV)
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htau_k2 = 5.2 (mV)
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ek (mV)
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cai (mM)
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}
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ASSIGNED {
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gbkpkj (mho/cm2)
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minf
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mtau (ms)
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hinf
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htau (ms)
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zinf
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ik (mA/cm2)
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}
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STATE {
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m FROM 0 TO 1
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z FROM 0 TO 1
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h FROM 0 TO 1
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}
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BREAKPOINT {
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SOLVE states METHOD cnexp
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gbkpkj = gbar * m * m * m * z * z * h
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ik = gbkpkj * (v - ek)
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}
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DERIVATIVE states {
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rates(v)
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m' = (minf - m) / mtau
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h' = (hinf - h) / htau
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z' = (zinf - z) / ztau
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}
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PROCEDURE rates(Vm (mV)) {
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LOCAL v
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v = Vm + 5
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minf = 1 / (1 + exp(-(v - (m_vh)) / m_k))
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m1 = mtau_y0 + (1. (ms)/(exp((v+ mtau_vh1)/mtau_k1)))
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mtau = m1 + (1. (ms)) * exp((v+mtau_vh2)/mtau_k2)
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zinf = 1/(1 + z_coef / cai)
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hinf = h_y0 + (1-h_y0) / (1+exp((v - h_vh)/h_k))
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htau = (htau_y0 + (1 (ms))/(exp((v + htau_vh1)/htau_k1)+exp((v+htau_vh2)/htau_k2)))
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}
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INITIAL {
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rates(v)
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m = minf
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z = zinf
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h = hinf
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}
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