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109 lines
2.3 KiB
109 lines
2.3 KiB
2 years ago
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TITLE KIR channel
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COMMENT
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Reference: Steephen JE, Manchanda R (2009) Differences in biophysical
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properties of nucleus accumbens medium spiny neurons emerging from
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inactivation of inward rectifying potassium currents. J Comput Neurosci [PubMed]
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Found on ModelDB, 1/21/2013 PBManis
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ENDCOMMENT
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NEURON {
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SUFFIX KIR
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USEION k READ ek WRITE ik
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RANGE g, ik, gbar
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GLOBAL minf, mtau
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}
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UNITS {
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(mA) = (milliamp)
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(uA) = (microamp)
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(mV) = (millivolt)
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(mS) = (millimho)
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}
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PARAMETER {
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celsius (degC)
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ek (mV)
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gbar = 1.4e-4 (mho/cm2) <0,1e9>
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m_vh = -82 (mV) : half activation
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m_ve = 13 (mV) : slope
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}
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ASSIGNED {
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v (mV)
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g (mho/cm2)
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ik (mA/cm2)
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minf (1)
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mtau (ms)
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qt (1)
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}
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STATE {
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m
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}
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BREAKPOINT {
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SOLVE states METHOD cnexp
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g = gbar*m
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ik = g*(v - ek)
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}
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INITIAL {
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qt = 3^((celsius-35)/10)
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rates(v)
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m = minf
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}
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DERIVATIVE states {
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rates(v)
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m' = (minf-m)/mtau
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}
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FUNCTION_TABLE tabmtau(v(mV)) (ms)
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: rates() computes rate and other constants at present v
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: call once from hoc to initialize inf at resting v
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PROCEDURE rates(v(mV)) {
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: mtau = tabmtau(v)
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mtau = tabmtau(v)/qt
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minf = 1/(1 + exp((v - m_vh)/m_ve))
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}
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COMMENT
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/* TABLES
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The tables here are built as vecs in hoc, and then loaded into the mod file arrays before use...
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*
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* Steephen, J. E., & Manchanda, R. (2009). Differences in biophysical properties of nucleus accumbens medium spiny neurons emerging from inactivation of inward rectifying potassium currents. J Comput Neurosci,
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* doi:10.1007/s10827-009-0161-7
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*/
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//KIR
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objref vecmtau_KIR, vecv_KIR
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vecmtau_KIR = new Vector()
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vecv_KIR = new Vector()
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vecv_KIR.indgen(-120, 0, 10)
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vecmtau_KIR.append(7.465, 7.465, 7.465, 8, 9.435, 10.755, 12.12, 13.795, 15.385, 14.285, 11.765, 8.89, 8) // At 35 deg C
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table_tabmtau_KIR(&vecmtau_KIR.x[0], vecv_KIR.size, &vecv_KIR.x[0])
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//inKIR
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objref vecv_inKIR, vechinf_inKIR, vechtau_inKIR, vecv_tau_inKIR
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vecv_tau_inKIR = new Vector()
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vechtau_inKIR= new Vector()
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vecv_tau_inKIR.append(-120,-90, -50)
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vechtau_inKIR.append(7.767, 15, 25.333) // At 35 deg C
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table_tabhtau_inKIR(&vechtau_inKIR.x[0],vecv_tau_inKIR.size, &vecv_tau_inKIR.x[0])
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vecv_inKIR = new Vector()
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vechinf_inKIR = new Vector()
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vecv_inKIR.append(-120,-90, -50)
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vechinf_inKIR.append(0, 0.13, 1)
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table_tabhinf_inKIR(&vechinf_inKIR.x[0], vecv_inKIR.size, &vecv_inKIR.x[0])
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table_tabmtau_inKIR(&vecmtau_KIR.x[0], vecv_KIR.size, &vecv_KIR.x[0])
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ENDCOMMENT
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