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104 lines
2.3 KiB
104 lines
2.3 KiB
2 years ago
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TITLE nacn.mod A sodium conductance for a ventral cochlear nucleus neuron model
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COMMENT
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NEURON implementation of Jason Rothman's measurements of VCN conductances.
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This file implements the average brain sodium current used in the Rothman model.
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In the absence of direct measurements in the VCN, this is a fair assumption.
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The model differs from the one used in Rothman et al, (1993) in that the steep
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voltage dependence of recovery from inactivation in that model is missing. This
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may affect the refractory period. To use the other model, use najsr.mod instead.
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Original implementation by Paul B. Manis, April (JHU) and Sept, (UNC)1999.
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File split implementaiton, April 1, 2004.
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Does not pass modlunit.
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Should work at 22C and scales by Rothman and Manis, 2003c for temperature
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Contact: pmanis@med.unc.edu
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ENDCOMMENT
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UNITS {
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(mA) = (milliamp)
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(mV) = (millivolt)
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(nA) = (nanoamp)
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}
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NEURON {
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THREADSAFE
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SUFFIX nacn
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USEION na READ ena WRITE ina
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RANGE gbar, gna, ina
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GLOBAL hinf, minf, htau, mtau
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}
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INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
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PARAMETER {
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v (mV)
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celsius (degC) : 22 (degC) model is defined on measurements made at room temp in Baltimore
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dt (ms)
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ena (mV)
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gbar = 0.07958 (mho/cm2) <0,1e9>
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q10tau = 3.0 : q10 for rates
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}
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STATE {
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m h
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}
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ASSIGNED {
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ina (mA/cm2)
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gna (mho/cm2)
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minf hinf
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mtau (ms) htau (ms)
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q10 ()
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}
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LOCAL mexp, hexp
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BREAKPOINT {
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SOLVE states METHOD cnexp
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gna = gbar*(m^3)*h
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ina = gna*(v - ena)
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}
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UNITSOFF
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INITIAL {
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rates(v)
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m = minf
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h = hinf
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}
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DERIVATIVE states { :Computes state variables m, h, and n
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rates(v) : at the current v and dt.
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m' = (minf - m)/mtau : m = m + mexp*(minf-m)
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h' = (hinf - h)/htau : h = h + hexp*(hinf-h)
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}
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LOCAL qt
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PROCEDURE rates(v) { :Computes rate and other constants at current v.
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:Call once from HOC to initialize inf at resting v.
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q10 = q10tau^((celsius - 22)/10) : if you don't like room temp, it can be changed!
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: average sodium channel
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minf = 1 / (1+exp(-(v + 38) / 7))
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hinf = 1 / (1+exp((v + 65) / 6))
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mtau = (10 / (5*exp((v+60) / 18) + 36*exp(-(v+60) / 25))) + 0.04
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mtau = mtau/q10
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htau = (100 / (7*exp((v+60) / 11) + 10*exp(-(v+60) / 25))) + 0.6
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htau = htau/q10
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}
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UNITSON
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