You can not select more than 25 topics
Topics must start with a letter or number, can include dashes ('-') and can be up to 35 characters long.
82 lines
1.6 KiB
82 lines
1.6 KiB
2 years ago
|
#!/usr/bin/python
|
||
|
|
"""
|
||
|
|
test and plot hcno stuff
|
||
|
|
|
||
|
|
"""
|
||
|
|
import numpy as np
|
||
|
|
import matplotlib.pyplot as plt
|
||
|
|
|
||
|
|
# Parameters#
|
||
|
|
gbar = 0.0005 # (mho/cm2)
|
||
|
|
|
||
|
|
vhalf1 = -50 # (mV) # v 1/2 for forward
|
||
|
|
vhalf2 = -84 # (mV) # v 1/2 for backward
|
||
|
|
gm1 = 0.3 ## (mV) # slope for forward
|
||
|
|
gm2 = 0.6 # # (mV) # slope for backward
|
||
|
|
zeta1 = 3 # (/ms)
|
||
|
|
# zeta2 = 3 # (/ms)
|
||
|
|
a01 = 0.008 # (/ms)
|
||
|
|
a02 = 0.0029 # (/ms)
|
||
|
|
frac = 0.0
|
||
|
|
c0 = 273.16 # (degC)
|
||
|
|
thinf = -66 # (mV) # inact inf slope
|
||
|
|
qinf = 7 # (mV) # inact inf slope
|
||
|
|
q10tau = 4.5 # from Magee (1998)
|
||
|
|
# v # (mV)
|
||
|
|
q10g = 4.5 # Cao and Oertel
|
||
|
|
celsius = 35.0
|
||
|
|
|
||
|
|
F = 9.648e4
|
||
|
|
R = 8.314
|
||
|
|
|
||
|
|
ct = 1e-3 * zeta1 * F / (R * (c0 + celsius))
|
||
|
|
|
||
|
|
q10 = q10tau ** (
|
||
|
|
(celsius - 33.0) / 10.0
|
||
|
|
) # (degC)) : if you don't like room temp, it can be changed!
|
||
|
|
|
||
|
|
|
||
|
|
def rates(v): # (mV)) {
|
||
|
|
tau1 = bet1(v) / (q10 * a01 * (1.0 + alp1(v)))
|
||
|
|
tau2 = bet2(v) / (q10 * a02 * (1.0 + alp2(v)))
|
||
|
|
hinf = 1.0 / (1.0 + np.exp((v - thinf) / qinf))
|
||
|
|
return tau1, tau2, hinf
|
||
|
|
|
||
|
|
|
||
|
|
def alp1(v): # (mV)) {
|
||
|
|
alp1 = np.exp((v - vhalf1) * ct)
|
||
|
|
return alp1
|
||
|
|
|
||
|
|
|
||
|
|
def bet1(v): # (mV)) {
|
||
|
|
bet1 = np.exp(gm1 * (v - vhalf1) * ct)
|
||
|
|
return bet1
|
||
|
|
|
||
|
|
|
||
|
|
def alp2(v): # (mV)) {
|
||
|
|
alp2 = np.exp((v - vhalf2) * ct)
|
||
|
|
return alp2
|
||
|
|
|
||
|
|
|
||
|
|
def bet2(v): # (mV)) {
|
||
|
|
bet2 = np.exp(gm2 * (v - vhalf2) * ct)
|
||
|
|
return bet2
|
||
|
|
|
||
|
|
|
||
|
|
def plots():
|
||
|
|
v = np.linspace(-120.0, 0.0, 120)
|
||
|
|
|
||
|
|
t1, t2, hi = rates(v)
|
||
|
|
# print(v)
|
||
|
|
plt.figure(1)
|
||
|
|
plt.plot(v, t1)
|
||
|
|
plt.plot(v, t2)
|
||
|
|
plt.figure(2)
|
||
|
|
plt.plot(v, hi)
|
||
|
|
plt.show()
|
||
|
|
|
||
|
|
|
||
|
|
# prevent sphinx from running this script at first build
|
||
|
|
if __name__ == "__main__":
|
||
|
|
plots()
|