# -*- encoding: utf-8 -*- from ._db import add_table_data #: Mouse synaptic convregence table mouse_convergence = u""" Convergence defines the average number of presynaptic cells of a particular type (rows) that synapse onto a single postsynaptic cell of a particular type (columns). This connectivity matrix is currently incomplete. Note: Bushy and pyramidal cells are known to have no (or very few) collaterals within the CN, and so they are not listed as presynaptic cells in this table. Octopus cells have collaterals (including in granule cell domains), and should be added to this table when more data are available (Golding et al., J. Neurosci. 15: 3138, 1995) ---------------------------------------------------------------------------------------------- bushy tstellate dstellate octopus pyramidal tuberculoventral sgc 3.3±0.6 [2] 6.5±1.0 [2] 35±0 [3] 60±0 [2] 48±0 [5] 24±0 [5] dstellate 7 [1] 20 [1] 3 [1] 0 [4] 15 [5] 15 [5] tstellate 0 [6] 0 [6] 0 [6] 0 [6] 0 [6] 0 [6] tuberculoventral 6 6 0 0 [4] 21 [5] 0 [7] pyramidal 0 0 0 0 0 0 ---------------------------------------------------------------------------------------------- [1] Guesses based on Campagnola & Manis 2014 [2] Cao, X. & Oertel, D. (2010). Auditory nerve fibers excite targets through synapses that vary in convergence, strength, and short-term plasticity. Journal of Neurophysiology, 104(5), 2308–20. Xie and Manis (unpublished): max EPSC = 3.4 ± 1.5 nA with ~0.3 nA steps (Cao and Oertel, 2010) = ~11 AN inputs. However neither we nor Cao and Oertel see that many clear steps in the responses, so use lower bound. [3] Lower bound based on estimates from unpublished data Xie and Manis (2017) Assumptions: No discernable step sizes when increasing shock intensity at ANFs in radiate multipolars (dstellate) Measured: 0.034 ± 15 nA sEPSC @ -70 mV Measured: Maximal current from AN stim = 1.2 ± 0.7 nA @ -70 mV Assuming that each AN provides 1 input, then N = ~35 [4] Octopus cells are devoid of inhibitory input (Golding et al., J. Neurosci., 1995) [5] Convergence from Hancock and Voigt, Ann. Biomed. Eng. 27, 1999 and Zheng and Voigt, Ann. Biomed. Eng., 34, 2006. Numbers are based on models for cat and gerbil, respectively. Adjusted to 1/2 to avoid overexciting TV cells in network model. [6] tstellate cells have collaterals within the CN. It has been proposed that they provide auditory-driven input to the DCN (Oertel and Young, ), and also synapse within the VCN (Oertel, SFN abstract). These parameters may need to be adjusted once the convergence and strength is known. [7] In the models of Hancock and Voigt (1999) and Zheng and Voigt (2006), the TV cells have no connections with each other. However, Kuo et al. (J. Neurophysiol., 2015) did see connections between pairs of TV cells in the mouse. """ add_table_data( "convergence", row_key="pre_type", col_key="post_type", species="mouse", data=mouse_convergence, ) mouse_convergence_range = u""" The convergence range table describes, for each type of connection from presynaptic (rows) to postsynaptic (columns), the variance in frequency of presynaptic cells relative to the postsynaptic cell. All values are expressed as the sigma for a lognormal distribution scaled to the CF of the postsynaptic cell. ---------------------------------------------------------------------------------------------- bushy tstellate dstellate octopus pyramidal tuberculoventral sgc 0.05 [1] 0.1 [1] 0.4 [1] 0.5 [5] 0.1 [1] 0.1 [1] dstellate 0.208 [2] 0.347 [2] 0.5 [1] 0 0.2 [1] 0.2 [1] tstellate 0.1 [4] 0.1 [4] 0 0 0 0 tuberculoventral 0.069 [3] 0.111 [3] 0 0 0.15 [1] 0 pyramidal 0 0 0 0 0 0 ---------------------------------------------------------------------------------------------- [1] Guess based on axonal / dendritic morphology. [2] Calculated from Campagnola & Manis 2014 fig. 7C Distribution widths are given in stdev(octaves), so we multiply by ln(2) to get the sigma for a lognormal distribution. DS->Bushy: ln(2) * 0.3 = 0.208 DS->TStellate: ln(2) * 0.5 = 0.347 [3] Calculated from Campagnola & Manis 2014 fig. 9C Distribution widths are given in stdev(octaves), so we multiply by ln(2) to get the sigma for a lognormal distribution. TV->Bushy: ln(2) * 0.10 = 0.069 TV->TStellate: ln(2) * 0.16 = 0.111 [4] Guess based on very limited information in Campagnola & Manis 2014 fig. 12 [5] Octopus cells get a wide range of ANF input (but weak on a per input basis) For example, see McGinley et al., 2012 or Spencer et al., 2012. """ add_table_data( "convergence_range", row_key="pre_type", col_key="post_type", species="mouse", data=mouse_convergence_range, ) # -------------------------------------------------------------------------------------------- guineapig_convergence = u""" Convergence defines the average number of presynaptic cells of a particular type (rows) that synapse onto a single postsynaptic cell of a particular type (columns). This connectivity matrix is currently incomplete. Note: Bushy and pyramidal cells are known to have no (or very few) collaterals within the CN, and so they are not listed as presynaptic cells in this table. Octopus cells have collaterals (including in granule cell domains), and should be added to this table when more data are available (Golding et al., J. Neurosci. 15: 3138, 1995) This table is just a guess... using mouse data... ---------------------------------------------------------------------------------------------- bushy tstellate dstellate octopus pyramidal tuberculoventral mso sgc 3.3±0.6 [2] 6.5±1.0 [2] 35±0 [3] 60±0 [2] 48±0 [5] 24±0 [5] 0 bushy 0 0 0 0 0 0 12 [8] dstellate 7 [1] 20 [1] 3 [1] 0 [4] 15 [5] 15 [5] 0 tstellate 0 [6] 0 [6] 0 [6] 0 [6] 0 [6] 0 [6] 0 tuberculoventral 6 6 0 0 [4] 21 [5] 0 [7] 0 pyramidal 0 0 0 0 0 0 0 ---------------------------------------------------------------------------------------------- [1] Guesses based on Campagnola & Manis 2014 (using mouse data on guinea pig cells) [2] Cao, X. & Oertel, D. (2010). Auditory nerve fibers excite targets through synapses that vary in convergence, strength, and short-term plasticity. Journal of Neurophysiology, 104(5), 2308–20. Xie and Manis (unpublished): max EPSC = 3.4 ± 1.5 nA with ~0.3 nA steps (Cao and Oertel, 2010) = ~11 AN inputs. However neither we nor Cao and Oertel see that many clear steps in the responses, so use lower bound. [3] Lower bound based on estimates from unpublished data Xie and Manis (2017) Assumptions: No discernable step sizes when increasing shock intensity at ANFs in radiate multipolars (dstellate) Measured: 0.034 ± 15 nA sEPSC @ -70 mV Measured: Maximal current from AN stim = 1.2 ± 0.7 nA @ -70 mV Assuming that each AN provides 1 input, then N = ~35 [4] Octopus cells are devoid of inhibitory input (Golding et al., J. Neurosci., 1995) [5] Convergence from Hancock and Voigt, Ann. Biomed. Eng. 27, 1999 and Zheng and Voigt, Ann. Biomed. Eng., 34, 2006. Numbers are based on models for cat and gerbil, respectively. Adjusted to 1/2 to avoid overexciting TV cells in network model. [6] tstellate cells have collaterals within the CN. It has been proposed that they provide auditory-driven input to the DCN (Oertel and Young, ), and also synapse within the VCN (Oertel, SFN abstract). These parameters may need to be adjusted once the convergence and strength is known. [7] In the models of Hancock and Voigt (1999) and Zheng and Voigt (2006), the TV cells have no connections with each other. However, Kuo et al. (J. Neurophysiol., 2015) did see connections between pairs of TV cells in the mouse. [8] Bushy convergence to MSO is a guess """ add_table_data( "convergence", row_key="pre_type", col_key="post_type", species="guineapig", data=guineapig_convergence, ) guineapig_convergence_range = u""" The convergence range table describes, for each type of connection from presynaptic (rows) to postsynaptic (columns), the variance in frequency of presynaptic cells relative to the postsynaptic cell. All values are expressed as the sigma for a lognormal distribution scaled to the CF of the postsynaptic cell. *** This table is just a guess - using data from mouse... **** ------------------------------------------------------------------------------------------------------- bushy tstellate dstellate octopus pyramidal tuberculoventral mso sgc 0.05 [1] 0.1 [1] 0.4 [1] 0.5 [5] 0.1 [1] 0.1 [1] 0 bushy 0 0 0 0 0 0 0.05 [6] dstellate 0.208 [2] 0.347 [2] 0.5 [1] 0 0.2 [1] 0.2 [1] 0 tstellate 0.1 [4] 0.1 [4] 0 0 0 0 0 tuberculoventral 0.069 [3] 0.111 [3] 0 0 0.15 [1] 0 0 pyramidal 0 0 0 0 0 0 0 -------------------------------------------------------------------------------------------------------- [1] Guess based on axonal / dendritic morphology. [2] Calculated from Campagnola & Manis 2014 fig. 7C (Using mouse data on guinea pig cells) Distribution widths are given in stdev(octaves), so we multiply by ln(2) to get the sigma for a lognormal distribution. DS->Bushy: ln(2) * 0.3 = 0.208 DS->TStellate: ln(2) * 0.5 = 0.347 [3] Calculated from Campagnola & Manis 2014 fig. 9C (Using mouse data on guinea pig cells) Distribution widths are given in stdev(octaves), so we multiply by ln(2) to get the sigma for a lognormal distribution. TV->Bushy: ln(2) * 0.10 = 0.069 TV->TStellate: ln(2) * 0.16 = 0.111 [4] Guess based on very limited information in Campagnola & Manis 2014 fig. 12 [5] Octopus cells get a wide range of ANF input (but weak on a per input basis) For example, see McGinley et al., 2012 or Spencer et al., 2012. [6] MSO convergence from bushy cells is a guess. """ add_table_data( "convergence_range", row_key="pre_type", col_key="post_type", species="guineapig", data=guineapig_convergence_range, )