: HH TEA-sensitive Purkinje potassium current : Created 8/5/02 - nwg NEURON { THREADSAFE SUFFIX kpkj USEION k READ ek WRITE ik RANGE gbar, ik, gk GLOBAL minf, hinf, mtau, htau } UNITS { (mV) = (millivolt) (mA) = (milliamp) } PARAMETER { v (mV) gbar = .004 (mho/cm2) mivh = -24 (mV) mik = 15.4 (mV) mty0 = .00012851 (s) mtvh1 = 100.7 (mV) mtk1 = 12.9 (mV) mtvh2 = -56.0 (mV) mtk2 = -23.1 (mV) hiy0 = .31 hiA = .78 hivh = -5.802 (mV) hik = 11.2 (mV) ek (mV) } ASSIGNED { gk (mho/cm2) ik (mA/cm2) minf mtau (ms) hinf htau (ms) } STATE { m h } INITIAL { rates(v) m = minf h = hinf } BREAKPOINT { SOLVE states METHOD cnexp gk = gbar * m^3 * h ik = gk * (v - ek) } DERIVATIVE states { rates(v) m' = (minf - m) / mtau h' = (hinf - h) / htau } PROCEDURE rates( Vm (mV)) { LOCAL v v = Vm + 11 (mV) : Account for Junction Potential minf = 1/(1+exp(-(v-mivh)/mik)) mtau = mtau_func(v) hinf = hiy0 + hiA/(1+exp((v-hivh)/hik)) htau = 1000 * htau_func(v) } FUNCTION mtau_func (v (mV)) (ms) { if (v < -35 (mV)) { mtau_func = (1000)*(3.4225e-5+.00498*exp(-v/-28.29 (mV)))*3 (s) } else { mtau_func = (1000)*(mty0 + 1(s)/(exp((v+mtvh1)/mtk1)+exp((v+mtvh2)/mtk2))) } } FUNCTION htau_func(Vm (mV)) (ms) { if ( Vm > 0) { htau_func = (1000)*(0.0012 (s) + 0.0023(s)*exp(-0.141 *Vm / 1 (mV))) } else { htau_func = (1000)*(1.2202e-05(s) + .012(s) * exp(-((Vm-(-56.3 (mV)))/49.6 (mV))^2)) } }