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142 lines
2.9 KiB
142 lines
2.9 KiB
TITLE ihpyr_adj.mod DCN pyramidal cell model H-current |
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COMMENT |
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This model is part a Dorsal Cochlear Nucleus Pyramidal point cell |
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based on kinetic data from Kanold and Manis (1999) and Kanold's dissertation (1999) |
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-- 15 Jan 1999 P. Manis |
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Added export of start states for some variables to do perturbation tests |
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These start values replace the "inf" values used in the initialization procedure |
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Note that if the start variable is set to a value less than 0, |
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then the default initialization will be done. Typically I use a value of -1 for this flagging |
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Note also that it is possible to set the initial values > 1 but this is meaningless in terms of |
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the present equations. |
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-- 5 Feb 1999 P. Manis |
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Added Patrick's version of ih as ihpyr |
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Model is from Destexhe and Babloyantz 1993; Destexhe et al. 1993 |
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2/10/02. P. Manis. |
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7/23/2014 P. Manis - separated from pyr.mod. |
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7/23/2018 P. Manis - created "ihpyr_adj" |
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ihpyr_adj has an adjustable q10 for fitting against experimental data |
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ENDCOMMENT |
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UNITS { |
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(mA) = (milliamp) |
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(mV) = (millivolt) |
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} |
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NEURON { |
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THREADSAFE |
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SUFFIX ihpyr_adj |
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USEION na READ ena WRITE ina |
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USEION k READ ek WRITE ik |
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NONSPECIFIC_CURRENT i |
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: USEION h READ eh WRITE ih VALENCE 1 |
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RANGE eh |
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: |
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RANGE gh, kh_m_inf, kh_n_inf, aih, gbar, ghvshift |
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RANGE kh_m_tau, kh_n_tau |
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GLOBAL q10, q10f |
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} |
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INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)} |
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PARAMETER { |
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v (mV) |
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celsius (degC) |
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dt (ms) |
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ek (mV) : = -81.5 (mV) |
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ena (mV) : = 50.0 (mV) |
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gbar = 0.00025 (mho/cm2) <0,1e9> |
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ghvshift = 0 (mV) |
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eh (mV) : = -43.0(mV) |
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q10 = 3.0 (1) |
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} |
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STATE { |
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khm khn |
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} |
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ASSIGNED { |
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gh (mho/cm2) |
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ina (mA/cm2) |
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ik (mA/cm2) |
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ih (mA/cm2) |
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i (mA/cm2) |
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kh_m_inf kh_n_inf |
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kh_m_tau kh_n_tau |
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aih |
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q10f (1) |
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} |
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BREAKPOINT { |
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SOLVE states METHOD cnexp |
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aih = khm*khn |
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gh = gbar*aih |
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ih = gh*(v - eh) |
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i = ih |
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} |
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UNITSOFF |
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INITIAL { |
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rates(v) |
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khm = kh_m_inf |
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khn = kh_n_inf |
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} |
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DERIVATIVE states { |
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rates(v) |
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khm' = (kh_m_inf - khm) / kh_m_tau |
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khn' = (kh_n_inf - khn) / kh_n_tau |
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} |
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: LOCAL q10f |
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PROCEDURE rates(v(mV)) { :Computes rate and other constants at current v. |
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:Call once from HOC to initialize inf at resting v. |
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q10f = q10^((celsius - 22)/10 (degC)) |
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:"kh" adaptation of Destexhe hyp-activated cation current by Patrick Kanold |
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: adding q10 does not shift activation curves |
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kh_m_inf = kh_m(v) |
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kh_n_inf = kh_n(v) |
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: adding the q10 just changes the rate for the taus (1/(a+b)) |
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kh_m_tau = kh_mt(v)/q10f |
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kh_n_tau = kh_nt(v)/q10f |
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} |
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: Make these as functions so we can view them from hoc, although this |
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: may slow things down a bit |
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FUNCTION kh_m(x (mV)) { |
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kh_m = 1/(1+exp((x+68.9+ghvshift)/6.5)) |
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} |
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FUNCTION kh_n(x (mV)) { |
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kh_n = 1/(1+exp((x+68.9+ghvshift)/6.5)) : same as kh_m, but for completeness, compute this |
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} |
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FUNCTION kh_mt(v (mV)) { |
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kh_mt = exp((v+183.6+ghvshift)/15.24) |
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} |
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FUNCTION kh_nt(v (mV)) { |
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kh_nt = exp((v+158.6+ghvshift)/11.2)/(1+exp((v+75+ghvshift)/5.5)) |
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} |
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