Alan
/
DCNmodel
1
0
Fork 0
Code Issues Pull Requests Projects Releases Wiki Activity
model of DCN pyramidal neuron
You can not select more than 25 topics Topics must start with a letter or number, can include dashes ('-') and can be up to 35 characters long.
1 Commit
1 Branch
0 Tags
1.3 MiB
Branch: master
Branches Tags
${ item.name }
Create tag ${ searchTerm }
Create branch ${ searchTerm }
from 'master'
${ noResults }
DCNmodel/cnmodel/data/ionchannels.py

583 lines
28 KiB
Raw Permalink Normal View History Unescape

copying to personal repo
2 years ago
# -*- encoding: utf-8 -*-
from ._db import add_table_data
"""
Ion channel density tables
All of the ion channel densities for the models implemented in cnmodel
are (or should be) stated here, and should not be modified in the
cnmodel code itself.
"""
add_table_data(
"RM03_channels",
row_key="field",
col_key="model_type",
species="guineapig",
data=u"""
This table describes the ion channel densities (and voltage shifts if necessary)
for different cell types in the original Rothman Manis 2003 model.
Data from Table 1, except for "octopus" cells, which is modified (see note 3)
map to cell: bushy-II bushy-II-I tstellate tstellate-t bushy-I-II octopus
-----------------------------------------------------------------------------------------------------------------------------------
II II-I I-c I-t I-II II-o
nacn_gbar 1000. [1] 1000. [1] 1000. [1] 1000. [1] 1000. [2] 1000. [3]
kht_gbar 150.0 [1] 150.0 [1] 150.0 [1] 80.0 [1] 150.0 [2] 150.0 [3]
klt_gbar 200.0 [1] 35.0 [1] 0.0 [1] 0.0 [1] 20.0 [2] 1000. [3]
ka_gbar 0.0 [1] 0.0 [1] 0.0 [1] 65.0 [1] 0.0 [2] 0.0 [3]
ih_gbar 20.0 [1] 3.5 [1] 0.5 [1] 0.5 [1] 2.0 [2] 30.0 [3]
leak_gbar 2.0 [1] 2.0 [1] 2.0 [1] 2.0 [1] 2.0 [2] 2.0 [3]
leak_erev -65 [1] -65 [1] -65 [1] -65 [1] -65 [2] -65 [3]
na_type nacn [1] nacn [1] nacn [1] nacn [1] nacn [2] nacn [3]
ih_type ihvcn [1] ihvcn [1] ihvcn [1] ihvcn [1] ihvcn [2] ihvcn [3]
soma_Cap 12.0 [1] 12.0 [1] 12.0 [1] 12.0 [1] 12.0 [2] 25.0 [3]
e_k -84 [1] -84 [1] -84 [1] -84 [2] -84 [2] -84 [2]
e_na 50. [1] 50. [1] 50. [1] 50. [2] 50. [2] 50. [2]
ih_eh -43 [1] -43 [1] -43 [1] -43 [2] -43 [2] -43 [2]
-----------------------------------------------------------------------------------------------------------------------------------
[1] Rothman and Manis, 2003
Age "adult", Temperature=22C
Units are nS.
[2] Rothman and manis, 2003, model I-II
Some low-voltage K current, based on observations of
a single spike near threshold and regular firing for higher
currents (Xie and Manis, 2017)
[3] Derived from Rothman and Manis, 2003, model II
Large amounts of low-voltage K current, and elevated HCN. Conductances
based on Rothman and Manis, 2003; concept from Cao and Oertel
[4] Designation for elevated LTK and Ih for octopus cells
""",
)
add_table_data(
"XM13_channels",
row_key="field",
col_key="model_type",
species="mouse",
data=u"""
This table describes the REFERENCE ion channel densities (and voltage shifts if necessary)
for different cell types based on the Xie and Manis 2013 models for mouse.
The REFERENCE values are applied to "point" models, and to the soma of
compartmental models.
The names of the mechanisms must match a channel mechanism (Neuron .mod files)
and the following _(gbar, vshift, etc) must match an attribute of that channel
that can be accessed.
-----------------------------------------------------------------------------------------------------------------------------------
II II-I I-c I-II I-t
nav11_gbar 0000. [4] 0000. [4] 000. [4] 0. [4] 3000. [4]
nacn_gbar 1000. [1] 1000. [1] 3000. [1] 0000. [2] 0000. [1]
na_gbar 1000. [1] 1000. [1] 3000. [1] 1800. [2] 0000. [1]
kht_gbar 58.0 [1] 58.0 [1] 500.0 [1] 150.0 [2] 500.0 [1]
klt_gbar 80.0 [1] 20.0 [1] 0.0 [1] 14.0 [3] 0.0 [1]
ka_gbar 0.0 [1] 0.0 [1] 0.0 [1] 0.0 [2] 125.0 [1]
ihvcn_gbar 30.0 [1] 30.0 [1] 18.0 [1] 2.0 [2] 18.0 [1]
leak_gbar 2.0 [1] 2.0 [1] 8.0 [1] 2.0 [2] 8.0 [1]
leak_erev -65 [1] -65 [1] -65 [1] -65 [2] -65 [1]
na_type nacn [1] nav11 [1] nacn [1] na [3] nav11 [1]
ih_type ihvcn [1] ihvcn [1] ihvcn [1] ihvcn [2] ihvcn [1]
soma_Cap 26.0 [1] 26.0 [1] 25.0 [1] 25.0 [2] 25.0 [1]
nav11_vshift 4.3 [1] 4.3 [1] 4.3 [1] 4.3 [1] 4.3 [1]
e_k -84 [1] -84 [1] -84 [1] -70 [3] -84 [1]
e_na 50. [1] 50. [1] 50. [1] 55. [3] 50. [1]
ih_eh -43 [1] -43 [1] -43 [1] -43 [2] -43 [1]
-----------------------------------------------------------------------------------------------------------------------------------
[1] Uses channels from Rothman and Manis, 2003
Conductances are for Mouse bushy cells
Xie and Manis, 2013
Age "adult", Temperature=34C
Units are nS.
[2] Rothman and manis, 2003, model I-II
Some low-voltage K current, based on observations of
a single spike near threshold and regular firing for higher
currents (Xie and Manis, 2017)
[3] These values for the I-II (dstellate) are from the original checkpoint test
for cnmodel 12/2017.
[4] nav11 channels were used in original Xie and Manis (2013) ms, but are not
used for mice in the master distribution of cnmodel, which used only the nacn
channels.
""",
)
add_table_data(
"XM13_channels_compartments",
row_key="parameter",
col_key="compartment",
species="mouse",
model_type="II",
data=u"""
This table describes the ion channel densities relative to somatic densities,
e.g., relative to REFERENCE densities in the table XM13_channels.
and voltage shifts, for different compartments of the specified neuron,
Conductances will be calculated from the Model derived from Xie and Manis 2013 for mouse
(data table: mGVC_channels).
------------------------------------------------------------------------------------------------------------------------------------------------------------------
axon unmyelinatedaxon myelinatedaxon initialsegment hillock soma dendrite primarydendrite secondarydendrite
nav11_gbar 3.0 [1] 3.0 [1] 0.0 [1] 5.0 [1] 5.0 [1] 1.0 [1] 0.5 [1] 0.50 [1] 0.25 [1]
kht_gbar 1.0 [1] 2.0 [1] 0.01 [1] 2.0 [1] 2.0 [1] 1.0 [1] 0.5 [1] 0.5 [1] 0.25 [1]
klt_gbar 1.0 [1] 1.0 [1] 0.01 [1] 1.0 [1] 1.0 [1] 1.0 [1] 0.5 [1] 0.5 [1] 0.25 [1]
ihvcn_gbar 0.0 [1] 0.0 [1] 0.0 [1] 0.5 [1] 0.0 [1] 1.0 [1] 0.5 [1] 0.5 [1] 0.5 [1]
leak_gbar 1.0 [1] 0.25 [1] 0.25e-3 [1] 1.0 [1] 1.0 [1] 1.0 [1] 0.5 [1] 0.5 [1] 0.5 [1]
leak_erev -65. [1] -65. [1] -65. [1] -65. [1] -65. [1] -65. [1] -65. [1] -65. [1] -65. [1]
nav11_vshift 4.3 [1] 4.3 [1] 0.0 [1] 4.3 [1] 4.3 [1] 0.0 [1] 0.0 [1] 0.0 [1] 0.0 [1]
na_type nav11 nav11 nav11 nav11 nav11 nav11 nav11 nav11 nav11
ih_type ihvcn ihvcn ihvcn ihvcn ihvcn ihvcn ihvcn ihvcn ihvcn
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
[1] Scaling is relative to soma scaling. Numbers are estimates based on general distribution from literature on cortical neurons.
""",
)
# ***** BEGINNING OF XM13_Channels for nacncoop version of model
add_table_data(
"XM13nacncoop_channels",
row_key="field",
col_key="model_type",
species="mouse",
data=u"""
This table describes the REFERENCE ion channel densities (and voltage shifts if necessary)
for different cell types based on the Xie and Manis 2013 models for mouse, but using
the nacncoop mechanism (coooperative sodium channels)
!!!!!!!!!!!! USAGE OF THIS TABLE SHOULD BE CONSIDERED EXPERIMENTAL !!!!!!!!!!!!!!
The REFERENCE values are applied to "point" models, and to the soma of
compartmental models.
The names of the mechanisms must match a channel mechanism (Neuron .mod files)
and the following _(gbar, vshift, etc) must match an attribute of that channel
that can be accessed.
-----------------------------------------------------------------------------------------------------------------------------------
II II-I I-c I-II I-t
nacncoop_gbar 3000. [4] 1000. [4] 1000. [4] 1000. [4] 1000. [4]
kht_gbar 58.0 [1] 58.0 [1] 500.0 [1] 150.0 [2] 500.0 [1]
klt_gbar 80.0 [1] 20.0 [1] 0.0 [1] 14.0 [3] 0.0 [1]
ka_gbar 0.0 [1] 0.0 [1] 0.0 [1] 0.0 [2] 125.0 [1]
ihvcn_gbar 30.0 [1] 30.0 [1] 18.0 [1] 2.0 [2] 18.0 [1]
leak_gbar 2.0 [1] 2.0 [1] 8.0 [1] 2.0 [2] 8.0 [1]
leak_erev -65 [1] -65 [1] -65 [1] -65 [2] -65 [1]
na_type nacncoop [1] nacncoop [1] nacncoop [1] nacncoop [3] nacncoop [1]
ih_type ihvcn [1] ihvcn [1] ihvcn [1] ihvcn [2] ihvcn [1]
soma_Cap 26.0 [1] 26.0 [1] 25.0 [1] 25.0 [2] 25.0 [1]
nacncoop_vshift 0.0 [1] 0.0 [1] 0.0 [1] 0.0 [1] 0.0 [1]
e_k -84 [1] -84 [1] -84 [1] -70 [3] -84 [1]
e_na 50. [1] 50. [1] 50. [1] 55. [3] 50. [1]
ih_eh -43 [1] -43 [1] -43 [1] -43 [2] -43 [1]
-----------------------------------------------------------------------------------------------------------------------------------
[1] Uses channels from Xie and Manis, 2013
Age "adult", Temperature=34C
Units are nS.
[2] Rothman and manis, 2003, model I-II
Some low-voltage K current, based on observations of
a single spike near threshold and regular firing for higher
currents (Xie and Manis, 2017)
[3] These values for the I-II (dstellate) are from the original checkpoint test
for cnmodel 12/2017.
[4] nav11 channels were used in original Xie and Manis (2013) ms,
However, this version uses cooperative na channels for faster activation
""",
)
add_table_data(
"XM13nacncooop_channels_compartments",
row_key="parameter",
col_key="compartment",
species="mouse",
model_type="II",
data=u"""
!!!!!!!!!!!! USAGE OF THIS TABLE SHOULD BE CONSIDERED EXPERIMENTAL !!!!!!!!!!!!!!
This table describes the ion channel densities relative to somatic densities,
e.g., relative to REFERENCE densities in the table XM13_nacncoop_channels.
and voltage shifts, for different compartments of the specified neuron,
Conductances will be calculated from the Model derived from Xie and Manis 2013 for mouse
------------------------------------------------------------------------------------------------------------------------------------------------------------------
axon unmyelinatedaxon myelinatedaxon initialsegment hillock soma dendrite primarydendrite secondarydendrite
nacncoop_gbar 3.0 [1] 3.0 [1] 0.0 [1] 5.0 [1] 5.0 [1] 1.0 [1] 0.5 [1] 0.50 [1] 0.25 [1]
kht_gbar 1.0 [1] 2.0 [1] 0.01 [1] 2.0 [1] 2.0 [1] 1.0 [1] 0.5 [1] 0.5 [1] 0.25 [1]
klt_gbar 1.0 [1] 1.0 [1] 0.01 [1] 1.0 [1] 1.0 [1] 1.0 [1] 0.5 [1] 0.5 [1] 0.25 [1]
ihvcn_gbar 0.0 [1] 0.0 [1] 0.0 [1] 0.5 [1] 0.0 [1] 1.0 [1] 0.5 [1] 0.5 [1] 0.5 [1]
leak_gbar 1.0 [1] 0.25 [1] 0.25e-3 [1] 1.0 [1] 1.0 [1] 1.0 [1] 0.5 [1] 0.5 [1] 0.5 [1]
leak_erev -65. [1] -65. [1] -65. [1] -65. [1] -65. [1] -65. [1] -65. [1] -65. [1] -65. [1]
nacncoop_vshift 0.0 [1] 0.0 [1] 0.0 [1] 0.0 [1] 0.0 [1] 0.0 [1] 0.0 [1] 0.0 [1] 0.0 [1]
na_type nacncoop nacncoop nacncoop nacncoop nacncoop nacncoop nacncoop nacncoop nacncoop
ih_type ihvcn ihvcn ihvcn ihvcn ihvcn ihvcn ihvcn ihvcn ihvcn
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
[1] Scaling is relative to soma scaling. Numbers are estimates based on general distribution from literature on cortical neurons.
""",
)
# ***** END OF XM13_Channels for nacncoop version of model
add_table_data(
"mGBC_channels",
row_key="field",
col_key="model_type",
species="mouse",
data=u"""
This table describes the REFERENCE ion channel densities (and voltage shifts if necessary)
for different cell types based on the Xie and Manis 2013 models for mouse.
The REFERENCE values are applied to "point" models, and to the soma of
compartmental models.
The names of the mechanisms must match a channel mechanism (Neuron .mod files)
and the following _(gbar, vshift, etc) must match an attribute of that channel
that can be accessed.
-----------------------------------------------------------------------------------------------------------------------------------
II II-I I-c I-II I-t
nav11_gbar 1600. [1] 1600. [1] 3000. [1] 1600. [2] 3000. [1]
kht_gbar 58.0 [1] 58.0 [1] 500.0 [1] 150.0 [2] 500.0 [1]
klt_gbar 80.0 [1] 14.0 [1] 0.0 [1] 20.0 [2] 0.0 [1]
ka_gbar 0.0 [1] 0.0 [1] 0.0 [1] 0.0 [2] 125.0 [1]
ihvcn_gbar 30.0 [1] 30.0 [1] 18.0 [1] 2.0 [2] 18.0 [1]
leak_gbar 2.0 [1] 2.0 [1] 8.0 [1] 2.0 [2] 8.0 [1]
leak_erev -65 [1] -65 [1] -65 [1] -65 [2] -65 [1]
na_type nav11 [1] nav11 [1] nav11 [1] nav11 [1] nav11 [1]
ih_type ihvcn [1] ihvcn [1] ihvcn [1] ihvcn [2] ihvcn [1]
soma_Cap 26.0 [1] 26.0 [1] 25.0 [1] 26.0 [2] 25.0 [1]
nav11_vshift 4.3 [1] 4.3 [1] 4.3 [1] 4.3 [1] 4.3 [1]
e_k -84 [1] -84 [1] -84 [1] -84 [2] -84 [1]
e_na 50. [1] 50. [1] 50. [1] 50. [2] 50. [1]
ih_eh -43 [1] -43 [1] -43 [1] -43 [2] -43 [1]
-----------------------------------------------------------------------------------------------------------------------------------
[1] Uses channels from Rothman and Manis, 2003, except for Na channels
Conductances are for Mouse bushy cells
Xie and Manis, 2013
Age "adult", Temperature=34C
Units are nS.
[2] Rothman and Manis, 2003, model I-II
Some low-voltage K current, based on observations of
a single spike near threshold and regular firing for higher
currents (Xie and Manis, 2017)
""",
)
add_table_data(
"mGBC_channels_compartments",
row_key="parameter",
col_key="compartment",
species="mouse",
model_type="II",
data=u"""
This table describes the ion channel densities relative to somatic densities,
e.g., relative to REFERENCE densities in the table XM13_channels.
and voltage shifts, for different compartments of the specified neuron,
Conductances will be calculated from the Model for Xie and Manis 2013 for mouse
(data table: XM13_channels).
------------------------------------------------------------------------------------------------------------------------------------------------------------------
axon unmyelinatedaxon myelinatedaxon initialsegment hillock soma dendrite primarydendrite secondarydendrite
nav11_gbar 3.0 [1] 3.0 [1] 0.0 [1] 3.0 [1] 2.0 [1] 1.0 [1] 0.25 [1] 0.25 [1] 0.25 [1]
kht_gbar 1.0 [1] 2.0 [1] 0.01 [1] 2.0 [1] 2.0 [1] 1.0 [1] 0.5 [1] 0.5 [1] 0.25 [1]
klt_gbar 1.0 [1] 1.0 [1] 0.01 [1] 1.0 [1] 1.0 [1] 1.0 [1] 0.5 [1] 0.5 [1] 0.25 [1]
ihvcn_gbar 0.0 [1] 0.0 [1] 0.0 [1] 0.5 [1] 0.0 [1] 1.0 [1] 0.5 [1] 0.5 [1] 0.5 [1]
leak_gbar 1.0 [1] 0.25 [1] 0.25e-3 [1] 1.0 [1] 1.0 [1] 1.0 [1] 0.5 [1] 0.5 [1] 0.5 [1]
leak_erev -65. [1] -65. [1] -65. [1] -65. [1] -65. [1] -65. [1] -65. [1] -65. [1] -65. [1]
nav11_vshift 4.3 [1] 4.3 [1] 0.0 [1] 4.3 [1] 4.3 [1] 0.0 [1] 0.0 [1] 0.0 [1] 0.0 [1]
na_type nav11 nav11 nav11 nav11 nav11 nav11 nav11 nav11 nav11
ih_type ihvcn ihvcn ihvcn ihvcn ihvcn ihvcn ihvcn ihvcn ihvcn
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
[1] Scaling is relative to soma scaling. Numbers are estimates based on general distribution from literature on cortical neurons.
""",
)
add_table_data(
"POK_channels",
row_key="field",
col_key="cell_type",
species="rat",
data=u"""
This table describes the ion channel densities and voltage shifts for rat DCN pyramidal cells,
from Kanold and Manis, 2001
------------------------------------------------------------------------------------------------------------------------------------------
pyramidal
soma_napyr_gbar 350.0 [1]
soma_nap_gbar 0.
soma_kdpyr_gbar 80.0 [1]
soma_kcnq_gbar 0.
soma_kif_gbar 150.0 [1]
soma_kis_gbar 40.0 [1]
soma_ihpyr_gbar 2.8 [1]
soma_leak_gbar 2.8 [1]
soma_leak_erev -62.0 [1]
soma_e_na 50. [1]
soma_e_k -81.5 [1]
soma_e_h -43.0 [1]
soma_natype napyr
soma_Cap 12 [1]
------------------------------------------------------------------------------------------------------------------------------------------
[1] Kanold and Manis, 1999, 2001, 2005
Age P11-14, Temperature=22C
Units are nS.
[2] Adjustable q10 added for fitting
soma_ihpyr_adj_q10 1.0 [2] (removed for testing)
""",
)
add_table_data(
"CW_channels",
row_key="field",
col_key="cell_type",
species="mouse",
data=u"""
This table describes the ion channel densities and voltage shifts
for a mouse carthweel cell model.
Ad-hoc model, based on a Purkinje cell model (ref [1]).
-----------------------------------------------------------------------------------------------------------------------------------
cartwheel
soma_narsg_gbar 500.0 [1]
soma_bkpkj_gbar 2.0
soma_kpkj_gbar 100. [1]
soma_kpkj2_gbar 50.
soma_kpkjslow_gbar 150 [1]
soma_kpksk_gbar 25.0 [1]
soma_lkpkj_gbar 5.0 [1]
soma_hpkj_gbar 5.0 [1]
soma_e_na 50. [1]
soma_e_k -80.0 [1]
soma_hpkj_eh -43.0 [1]
soma_lkpkj_e -65.0 [1]
soma_e_ca 50.
soma_na_type narsg
soma_pcabar 0.00015 [1]
soma_Dia 18
-----------------------------------------------------------------------------------------------------------------------------------
[1] Channels from Khaliq, Gouwens and Raman, J. Neurosci. 2003
Conductance levels modified.
""",
)
add_table_data(
"TV_channels",
row_key="field",
col_key="cell_type",
species="mouse",
data=u"""
This table describes the ion channel densities and voltage shifts
for a mouse tuberculoventral cell model.
Ad-hoc model, based on the t-stellate cell model, but adjusted
to match the data from Kuo and Trussell.
-----------------------------------------------------------------------------------------------------------------------------------
TVmouse
soma_nacncoop_gbar 5800.0 [2]
soma_kht_gbar 400.0 [1]
soma_ihvcn_gbar 2.5 [2]
soma_ka_gbar 65.0 [1]
soma_leak_gbar 4.5 [1]
soma_leak_erev -72.0 [1]
soma_e_na 50. [1]
soma_e_k -81.5 [1]
soma_ihvcn_eh -43.0 [1]
soma_na_type nacncoop [2]
soma_Cap 35 [1]
-----------------------------------------------------------------------------------------------------------------------------------
[1] Values obtained from brute force runs and comparision to
FI curve from Kuo, Lu and Trussell, J Neurophysiol. 2012 Aug 15;
108(4): 1186–1198.
[2] Cooperative sodium channel model, based on (see the mechanisms folder)
concepts and implementation similar to Oz et al. J.Comp. Neurosci. 39: 63, 2015,
and Huang et al., PloSOne 7:e37729, 2012.
""",
)
add_table_data(
"sgc_mouse_channels",
row_key="field",
col_key="cell_type",
species="mouse",
data=u"""
This table describes the ion channel densities (and voltage shifts if necessary)
for SGC cells, based on
-----------------------------------------------------------------------------------------------------------------------------------
sgc-a sgc-bm
sgc_name a bm
soma_na_gbar 350. [2] 350. [2]
soma_kht_gbar 58.0 [1] 58.0 [1]
soma_klt_gbar 80.0 [1] 80.0 [1]
soma_ihap_gbar 3.0 [3] 0.0 [1]
soma_ihap_eh -41.0 [3] -41.0 [3]
soma_ihbm_gbar 0.0 [3] 3.0 [3]
soma_ihbm_eh -41.0 [3] -41.0 [3]
soma_leak_gbar 2.0 [1] 2.0 [1]
soma_leak_erev -65 [1] -65 [1]
soma_na_type jsrna [2] jsrna [2]
soma_Cap 12.0 [1] 12.0 [1]
soma_e_k -84 [1] -84 [1]
soma_e_na 50. [1] 50. [1]
-----------------------------------------------------------------------------------------------------------------------------------
[1] Model is based on the mouse bushy cell model (XM13, above),
but with a fast sodium channel from Rothman et al, 1993. and Ih currents
from Liu et al. 2014
[2] Sodium channel from Rothman, Young and Manis, J Neurophysiol. 1993 Dec;70(6):2562-83.
[3] Ih Currents from Liu, Manis, Davis, J Assoc Res Otolaryngol. 2014 Aug;15(4):585-99.
doi: 10.1007/s10162-014-0446-z. Epub 2014 Feb 21.
Age "P10" (cultured SGC cells), Original data temperature=22C.
Units are nS.
""",
)
add_table_data(
"sgc_guineapig_channels",
row_key="field",
col_key="cell_type",
species="guineapig",
data=u"""
This table describes the ion channel densities (and voltage shifts if necessary)
for a model SGC cell, which is based on a bushy cell with a different Na channel.
-----------------------------------------------------------------------------------------------------------------------------------
sgc-a sgc-bm
sgc_name a bm
soma_na_gbar 1000. [2] 1000. [2]
soma_kht_gbar 150.0 [1] 150.0 [1]
soma_klt_gbar 200.0 [1] 200.0 [1]
soma_ihap_gbar 3.0 [3] 0.0 [3]
soma_ihap_eh -41.0 [3] -41.0 [3]
soma_ihbm_gbar 0.0 [3] 3.0 [3]
soma_ihbm_eh -41.0 [3] -41.0 [3]
soma_leak_gbar 2.0 [1] 2.0 [1]
soma_leak_erev -65 [1] -65 [1]
soma_na_type jsrna [2] jsrna [2]
soma_Cap 12.0 [1] 12.0 [1]
soma_e_k -84 [1] -84 [1]
soma_e_na 50. [1] 50. [1]
-----------------------------------------------------------------------------------------------------------------------------------
[1] Model is based on the guinea pig bushy cell model (RM03, above),
but with a fast sodium channel from Rothman et al, 1993. and Ih currents
from Liu et al. 2014
[2] Sodium channel from Rothman, Young and Manis, J Neurophysiol. 1993 Dec;70(6):2562-83.
[3] Ih Currents from Liu, Manis, Davis, J Assoc Res Otolaryngol. 2014 Aug;15(4):585-99.
doi: 10.1007/s10162-014-0446-z. Epub 2014 Feb 21.
Age "P10" (cultured SGC cells), Temperature=22C.
Units are nS.
""",
)
add_table_data(
"MSO_principal_channels",
row_key="field",
col_key="cell_type",
species="guineapig",
data=u"""
This table describes the ion channel densities
for a putative MSO principal neuron based on the original Rothman Manis 2003 model for bushy cells.
-----------------------------------------------------------------------------------------------------------------------------------
MSO-principal
MSO_name Principal
soma_na_gbar 1000. [1]
soma_kht_gbar 150.0 [1]
soma_klt_gbar 200.0 [1]
soma_ka_gbar 0.0 [1]
soma_ih_gbar 20.0 [1]
soma_leak_gbar 2.0 [1]
soma_leak_erev -65 [1]
soma_na_type nacn [1]
soma_ih_type ihvcn [1]
soma_Cap 12.0 [1]
soma_e_k -84 [1]
soma_e_na 50. [1]
soma_ih_eh -43 [1]
-----------------------------------------------------------------------------------------------------------------------------------
[1] This MSO neuron model is basied on Rothman and Manis, 2003 bushy cell, type II
Age "adult", Temperature=22C
Units are nS.
""",
)