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582 lines
28 KiB
582 lines
28 KiB
# -*- encoding: utf-8 -*- |
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from ._db import add_table_data |
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|
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""" |
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Ion channel density tables |
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All of the ion channel densities for the models implemented in cnmodel |
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are (or should be) stated here, and should not be modified in the |
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cnmodel code itself. |
|
|
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""" |
|
|
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add_table_data( |
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"RM03_channels", |
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row_key="field", |
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col_key="model_type", |
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species="guineapig", |
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data=u""" |
|
|
|
This table describes the ion channel densities (and voltage shifts if necessary) |
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for different cell types in the original Rothman Manis 2003 model. |
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Data from Table 1, except for "octopus" cells, which is modified (see note 3) |
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map to cell: bushy-II bushy-II-I tstellate tstellate-t bushy-I-II octopus |
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----------------------------------------------------------------------------------------------------------------------------------- |
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II II-I I-c I-t I-II II-o |
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|
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nacn_gbar 1000. [1] 1000. [1] 1000. [1] 1000. [1] 1000. [2] 1000. [3] |
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kht_gbar 150.0 [1] 150.0 [1] 150.0 [1] 80.0 [1] 150.0 [2] 150.0 [3] |
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klt_gbar 200.0 [1] 35.0 [1] 0.0 [1] 0.0 [1] 20.0 [2] 1000. [3] |
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ka_gbar 0.0 [1] 0.0 [1] 0.0 [1] 65.0 [1] 0.0 [2] 0.0 [3] |
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ih_gbar 20.0 [1] 3.5 [1] 0.5 [1] 0.5 [1] 2.0 [2] 30.0 [3] |
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leak_gbar 2.0 [1] 2.0 [1] 2.0 [1] 2.0 [1] 2.0 [2] 2.0 [3] |
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leak_erev -65 [1] -65 [1] -65 [1] -65 [1] -65 [2] -65 [3] |
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na_type nacn [1] nacn [1] nacn [1] nacn [1] nacn [2] nacn [3] |
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ih_type ihvcn [1] ihvcn [1] ihvcn [1] ihvcn [1] ihvcn [2] ihvcn [3] |
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soma_Cap 12.0 [1] 12.0 [1] 12.0 [1] 12.0 [1] 12.0 [2] 25.0 [3] |
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e_k -84 [1] -84 [1] -84 [1] -84 [2] -84 [2] -84 [2] |
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e_na 50. [1] 50. [1] 50. [1] 50. [2] 50. [2] 50. [2] |
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ih_eh -43 [1] -43 [1] -43 [1] -43 [2] -43 [2] -43 [2] |
|
|
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----------------------------------------------------------------------------------------------------------------------------------- |
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|
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[1] Rothman and Manis, 2003 |
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Age "adult", Temperature=22C |
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Units are nS. |
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|
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[2] Rothman and manis, 2003, model I-II |
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Some low-voltage K current, based on observations of |
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a single spike near threshold and regular firing for higher |
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currents (Xie and Manis, 2017) |
|
|
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[3] Derived from Rothman and Manis, 2003, model II |
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Large amounts of low-voltage K current, and elevated HCN. Conductances |
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based on Rothman and Manis, 2003; concept from Cao and Oertel |
|
|
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[4] Designation for elevated LTK and Ih for octopus cells |
|
|
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""", |
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) |
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|
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add_table_data( |
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"XM13_channels", |
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row_key="field", |
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col_key="model_type", |
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species="mouse", |
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data=u""" |
|
|
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This table describes the REFERENCE ion channel densities (and voltage shifts if necessary) |
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for different cell types based on the Xie and Manis 2013 models for mouse. |
|
|
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The REFERENCE values are applied to "point" models, and to the soma of |
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compartmental models. |
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The names of the mechanisms must match a channel mechanism (Neuron .mod files) |
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and the following _(gbar, vshift, etc) must match an attribute of that channel |
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that can be accessed. |
|
|
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----------------------------------------------------------------------------------------------------------------------------------- |
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II II-I I-c I-II I-t |
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|
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nav11_gbar 0000. [4] 0000. [4] 000. [4] 0. [4] 3000. [4] |
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nacn_gbar 1000. [1] 1000. [1] 3000. [1] 0000. [2] 0000. [1] |
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na_gbar 1000. [1] 1000. [1] 3000. [1] 1800. [2] 0000. [1] |
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kht_gbar 58.0 [1] 58.0 [1] 500.0 [1] 150.0 [2] 500.0 [1] |
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klt_gbar 80.0 [1] 20.0 [1] 0.0 [1] 14.0 [3] 0.0 [1] |
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ka_gbar 0.0 [1] 0.0 [1] 0.0 [1] 0.0 [2] 125.0 [1] |
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ihvcn_gbar 30.0 [1] 30.0 [1] 18.0 [1] 2.0 [2] 18.0 [1] |
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leak_gbar 2.0 [1] 2.0 [1] 8.0 [1] 2.0 [2] 8.0 [1] |
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leak_erev -65 [1] -65 [1] -65 [1] -65 [2] -65 [1] |
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na_type nacn [1] nav11 [1] nacn [1] na [3] nav11 [1] |
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ih_type ihvcn [1] ihvcn [1] ihvcn [1] ihvcn [2] ihvcn [1] |
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soma_Cap 26.0 [1] 26.0 [1] 25.0 [1] 25.0 [2] 25.0 [1] |
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nav11_vshift 4.3 [1] 4.3 [1] 4.3 [1] 4.3 [1] 4.3 [1] |
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e_k -84 [1] -84 [1] -84 [1] -70 [3] -84 [1] |
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e_na 50. [1] 50. [1] 50. [1] 55. [3] 50. [1] |
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ih_eh -43 [1] -43 [1] -43 [1] -43 [2] -43 [1] |
|
|
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----------------------------------------------------------------------------------------------------------------------------------- |
|
|
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[1] Uses channels from Rothman and Manis, 2003 |
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Conductances are for Mouse bushy cells |
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Xie and Manis, 2013 |
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Age "adult", Temperature=34C |
|
Units are nS. |
|
|
|
[2] Rothman and manis, 2003, model I-II |
|
Some low-voltage K current, based on observations of |
|
a single spike near threshold and regular firing for higher |
|
currents (Xie and Manis, 2017) |
|
|
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[3] These values for the I-II (dstellate) are from the original checkpoint test |
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for cnmodel 12/2017. |
|
|
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[4] nav11 channels were used in original Xie and Manis (2013) ms, but are not |
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used for mice in the master distribution of cnmodel, which used only the nacn |
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channels. |
|
|
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""", |
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) |
|
|
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add_table_data( |
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"XM13_channels_compartments", |
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row_key="parameter", |
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col_key="compartment", |
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species="mouse", |
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model_type="II", |
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data=u""" |
|
|
|
This table describes the ion channel densities relative to somatic densities, |
|
e.g., relative to REFERENCE densities in the table XM13_channels. |
|
and voltage shifts, for different compartments of the specified neuron, |
|
Conductances will be calculated from the Model derived from Xie and Manis 2013 for mouse |
|
(data table: mGVC_channels). |
|
|
|
------------------------------------------------------------------------------------------------------------------------------------------------------------------ |
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axon unmyelinatedaxon myelinatedaxon initialsegment hillock soma dendrite primarydendrite secondarydendrite |
|
|
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nav11_gbar 3.0 [1] 3.0 [1] 0.0 [1] 5.0 [1] 5.0 [1] 1.0 [1] 0.5 [1] 0.50 [1] 0.25 [1] |
|
kht_gbar 1.0 [1] 2.0 [1] 0.01 [1] 2.0 [1] 2.0 [1] 1.0 [1] 0.5 [1] 0.5 [1] 0.25 [1] |
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klt_gbar 1.0 [1] 1.0 [1] 0.01 [1] 1.0 [1] 1.0 [1] 1.0 [1] 0.5 [1] 0.5 [1] 0.25 [1] |
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ihvcn_gbar 0.0 [1] 0.0 [1] 0.0 [1] 0.5 [1] 0.0 [1] 1.0 [1] 0.5 [1] 0.5 [1] 0.5 [1] |
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leak_gbar 1.0 [1] 0.25 [1] 0.25e-3 [1] 1.0 [1] 1.0 [1] 1.0 [1] 0.5 [1] 0.5 [1] 0.5 [1] |
|
leak_erev -65. [1] -65. [1] -65. [1] -65. [1] -65. [1] -65. [1] -65. [1] -65. [1] -65. [1] |
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nav11_vshift 4.3 [1] 4.3 [1] 0.0 [1] 4.3 [1] 4.3 [1] 0.0 [1] 0.0 [1] 0.0 [1] 0.0 [1] |
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na_type nav11 nav11 nav11 nav11 nav11 nav11 nav11 nav11 nav11 |
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ih_type ihvcn ihvcn ihvcn ihvcn ihvcn ihvcn ihvcn ihvcn ihvcn |
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------------------------------------------------------------------------------------------------------------------------------------------------------------------- |
|
|
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[1] Scaling is relative to soma scaling. Numbers are estimates based on general distribution from literature on cortical neurons. |
|
|
|
|
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""", |
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) |
|
|
|
|
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# ***** BEGINNING OF XM13_Channels for nacncoop version of model |
|
|
|
|
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add_table_data( |
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"XM13nacncoop_channels", |
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row_key="field", |
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col_key="model_type", |
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species="mouse", |
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data=u""" |
|
|
|
This table describes the REFERENCE ion channel densities (and voltage shifts if necessary) |
|
for different cell types based on the Xie and Manis 2013 models for mouse, but using |
|
the nacncoop mechanism (coooperative sodium channels) |
|
|
|
!!!!!!!!!!!! USAGE OF THIS TABLE SHOULD BE CONSIDERED EXPERIMENTAL !!!!!!!!!!!!!! |
|
|
|
The REFERENCE values are applied to "point" models, and to the soma of |
|
compartmental models. |
|
The names of the mechanisms must match a channel mechanism (Neuron .mod files) |
|
and the following _(gbar, vshift, etc) must match an attribute of that channel |
|
that can be accessed. |
|
|
|
----------------------------------------------------------------------------------------------------------------------------------- |
|
II II-I I-c I-II I-t |
|
|
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nacncoop_gbar 3000. [4] 1000. [4] 1000. [4] 1000. [4] 1000. [4] |
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kht_gbar 58.0 [1] 58.0 [1] 500.0 [1] 150.0 [2] 500.0 [1] |
|
klt_gbar 80.0 [1] 20.0 [1] 0.0 [1] 14.0 [3] 0.0 [1] |
|
ka_gbar 0.0 [1] 0.0 [1] 0.0 [1] 0.0 [2] 125.0 [1] |
|
ihvcn_gbar 30.0 [1] 30.0 [1] 18.0 [1] 2.0 [2] 18.0 [1] |
|
leak_gbar 2.0 [1] 2.0 [1] 8.0 [1] 2.0 [2] 8.0 [1] |
|
leak_erev -65 [1] -65 [1] -65 [1] -65 [2] -65 [1] |
|
na_type nacncoop [1] nacncoop [1] nacncoop [1] nacncoop [3] nacncoop [1] |
|
ih_type ihvcn [1] ihvcn [1] ihvcn [1] ihvcn [2] ihvcn [1] |
|
soma_Cap 26.0 [1] 26.0 [1] 25.0 [1] 25.0 [2] 25.0 [1] |
|
nacncoop_vshift 0.0 [1] 0.0 [1] 0.0 [1] 0.0 [1] 0.0 [1] |
|
e_k -84 [1] -84 [1] -84 [1] -70 [3] -84 [1] |
|
e_na 50. [1] 50. [1] 50. [1] 55. [3] 50. [1] |
|
ih_eh -43 [1] -43 [1] -43 [1] -43 [2] -43 [1] |
|
|
|
----------------------------------------------------------------------------------------------------------------------------------- |
|
|
|
[1] Uses channels from Xie and Manis, 2013 |
|
Age "adult", Temperature=34C |
|
Units are nS. |
|
|
|
[2] Rothman and manis, 2003, model I-II |
|
Some low-voltage K current, based on observations of |
|
a single spike near threshold and regular firing for higher |
|
currents (Xie and Manis, 2017) |
|
|
|
[3] These values for the I-II (dstellate) are from the original checkpoint test |
|
for cnmodel 12/2017. |
|
|
|
[4] nav11 channels were used in original Xie and Manis (2013) ms, |
|
However, this version uses cooperative na channels for faster activation |
|
|
|
""", |
|
) |
|
|
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add_table_data( |
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"XM13nacncooop_channels_compartments", |
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row_key="parameter", |
|
col_key="compartment", |
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species="mouse", |
|
model_type="II", |
|
data=u""" |
|
|
|
!!!!!!!!!!!! USAGE OF THIS TABLE SHOULD BE CONSIDERED EXPERIMENTAL !!!!!!!!!!!!!! |
|
|
|
This table describes the ion channel densities relative to somatic densities, |
|
e.g., relative to REFERENCE densities in the table XM13_nacncoop_channels. |
|
and voltage shifts, for different compartments of the specified neuron, |
|
Conductances will be calculated from the Model derived from Xie and Manis 2013 for mouse |
|
|
|
------------------------------------------------------------------------------------------------------------------------------------------------------------------ |
|
axon unmyelinatedaxon myelinatedaxon initialsegment hillock soma dendrite primarydendrite secondarydendrite |
|
|
|
nacncoop_gbar 3.0 [1] 3.0 [1] 0.0 [1] 5.0 [1] 5.0 [1] 1.0 [1] 0.5 [1] 0.50 [1] 0.25 [1] |
|
kht_gbar 1.0 [1] 2.0 [1] 0.01 [1] 2.0 [1] 2.0 [1] 1.0 [1] 0.5 [1] 0.5 [1] 0.25 [1] |
|
klt_gbar 1.0 [1] 1.0 [1] 0.01 [1] 1.0 [1] 1.0 [1] 1.0 [1] 0.5 [1] 0.5 [1] 0.25 [1] |
|
ihvcn_gbar 0.0 [1] 0.0 [1] 0.0 [1] 0.5 [1] 0.0 [1] 1.0 [1] 0.5 [1] 0.5 [1] 0.5 [1] |
|
leak_gbar 1.0 [1] 0.25 [1] 0.25e-3 [1] 1.0 [1] 1.0 [1] 1.0 [1] 0.5 [1] 0.5 [1] 0.5 [1] |
|
leak_erev -65. [1] -65. [1] -65. [1] -65. [1] -65. [1] -65. [1] -65. [1] -65. [1] -65. [1] |
|
nacncoop_vshift 0.0 [1] 0.0 [1] 0.0 [1] 0.0 [1] 0.0 [1] 0.0 [1] 0.0 [1] 0.0 [1] 0.0 [1] |
|
na_type nacncoop nacncoop nacncoop nacncoop nacncoop nacncoop nacncoop nacncoop nacncoop |
|
ih_type ihvcn ihvcn ihvcn ihvcn ihvcn ihvcn ihvcn ihvcn ihvcn |
|
-------------------------------------------------------------------------------------------------------------------------------------------------------------------- |
|
|
|
[1] Scaling is relative to soma scaling. Numbers are estimates based on general distribution from literature on cortical neurons. |
|
|
|
|
|
""", |
|
) |
|
|
|
# ***** END OF XM13_Channels for nacncoop version of model |
|
|
|
add_table_data( |
|
"mGBC_channels", |
|
row_key="field", |
|
col_key="model_type", |
|
species="mouse", |
|
data=u""" |
|
|
|
This table describes the REFERENCE ion channel densities (and voltage shifts if necessary) |
|
for different cell types based on the Xie and Manis 2013 models for mouse. |
|
|
|
The REFERENCE values are applied to "point" models, and to the soma of |
|
compartmental models. |
|
The names of the mechanisms must match a channel mechanism (Neuron .mod files) |
|
and the following _(gbar, vshift, etc) must match an attribute of that channel |
|
that can be accessed. |
|
|
|
----------------------------------------------------------------------------------------------------------------------------------- |
|
II II-I I-c I-II I-t |
|
|
|
nav11_gbar 1600. [1] 1600. [1] 3000. [1] 1600. [2] 3000. [1] |
|
kht_gbar 58.0 [1] 58.0 [1] 500.0 [1] 150.0 [2] 500.0 [1] |
|
klt_gbar 80.0 [1] 14.0 [1] 0.0 [1] 20.0 [2] 0.0 [1] |
|
ka_gbar 0.0 [1] 0.0 [1] 0.0 [1] 0.0 [2] 125.0 [1] |
|
ihvcn_gbar 30.0 [1] 30.0 [1] 18.0 [1] 2.0 [2] 18.0 [1] |
|
leak_gbar 2.0 [1] 2.0 [1] 8.0 [1] 2.0 [2] 8.0 [1] |
|
leak_erev -65 [1] -65 [1] -65 [1] -65 [2] -65 [1] |
|
na_type nav11 [1] nav11 [1] nav11 [1] nav11 [1] nav11 [1] |
|
ih_type ihvcn [1] ihvcn [1] ihvcn [1] ihvcn [2] ihvcn [1] |
|
soma_Cap 26.0 [1] 26.0 [1] 25.0 [1] 26.0 [2] 25.0 [1] |
|
nav11_vshift 4.3 [1] 4.3 [1] 4.3 [1] 4.3 [1] 4.3 [1] |
|
e_k -84 [1] -84 [1] -84 [1] -84 [2] -84 [1] |
|
e_na 50. [1] 50. [1] 50. [1] 50. [2] 50. [1] |
|
ih_eh -43 [1] -43 [1] -43 [1] -43 [2] -43 [1] |
|
|
|
----------------------------------------------------------------------------------------------------------------------------------- |
|
|
|
[1] Uses channels from Rothman and Manis, 2003, except for Na channels |
|
Conductances are for Mouse bushy cells |
|
Xie and Manis, 2013 |
|
Age "adult", Temperature=34C |
|
Units are nS. |
|
|
|
[2] Rothman and Manis, 2003, model I-II |
|
Some low-voltage K current, based on observations of |
|
a single spike near threshold and regular firing for higher |
|
currents (Xie and Manis, 2017) |
|
|
|
|
|
""", |
|
) |
|
|
|
|
|
add_table_data( |
|
"mGBC_channels_compartments", |
|
row_key="parameter", |
|
col_key="compartment", |
|
species="mouse", |
|
model_type="II", |
|
data=u""" |
|
|
|
This table describes the ion channel densities relative to somatic densities, |
|
e.g., relative to REFERENCE densities in the table XM13_channels. |
|
and voltage shifts, for different compartments of the specified neuron, |
|
Conductances will be calculated from the Model for Xie and Manis 2013 for mouse |
|
(data table: XM13_channels). |
|
|
|
------------------------------------------------------------------------------------------------------------------------------------------------------------------ |
|
axon unmyelinatedaxon myelinatedaxon initialsegment hillock soma dendrite primarydendrite secondarydendrite |
|
|
|
nav11_gbar 3.0 [1] 3.0 [1] 0.0 [1] 3.0 [1] 2.0 [1] 1.0 [1] 0.25 [1] 0.25 [1] 0.25 [1] |
|
kht_gbar 1.0 [1] 2.0 [1] 0.01 [1] 2.0 [1] 2.0 [1] 1.0 [1] 0.5 [1] 0.5 [1] 0.25 [1] |
|
klt_gbar 1.0 [1] 1.0 [1] 0.01 [1] 1.0 [1] 1.0 [1] 1.0 [1] 0.5 [1] 0.5 [1] 0.25 [1] |
|
ihvcn_gbar 0.0 [1] 0.0 [1] 0.0 [1] 0.5 [1] 0.0 [1] 1.0 [1] 0.5 [1] 0.5 [1] 0.5 [1] |
|
leak_gbar 1.0 [1] 0.25 [1] 0.25e-3 [1] 1.0 [1] 1.0 [1] 1.0 [1] 0.5 [1] 0.5 [1] 0.5 [1] |
|
leak_erev -65. [1] -65. [1] -65. [1] -65. [1] -65. [1] -65. [1] -65. [1] -65. [1] -65. [1] |
|
nav11_vshift 4.3 [1] 4.3 [1] 0.0 [1] 4.3 [1] 4.3 [1] 0.0 [1] 0.0 [1] 0.0 [1] 0.0 [1] |
|
na_type nav11 nav11 nav11 nav11 nav11 nav11 nav11 nav11 nav11 |
|
ih_type ihvcn ihvcn ihvcn ihvcn ihvcn ihvcn ihvcn ihvcn ihvcn |
|
------------------------------------------------------------------------------------------------------------------------------------------------------------------- |
|
|
|
[1] Scaling is relative to soma scaling. Numbers are estimates based on general distribution from literature on cortical neurons. |
|
|
|
|
|
""", |
|
) |
|
|
|
|
|
add_table_data( |
|
"POK_channels", |
|
row_key="field", |
|
col_key="cell_type", |
|
species="rat", |
|
data=u""" |
|
|
|
This table describes the ion channel densities and voltage shifts for rat DCN pyramidal cells, |
|
from Kanold and Manis, 2001 |
|
|
|
------------------------------------------------------------------------------------------------------------------------------------------ |
|
pyramidal |
|
|
|
soma_napyr_gbar 350.0 [1] |
|
soma_nap_gbar 0. |
|
soma_kdpyr_gbar 80.0 [1] |
|
soma_kcnq_gbar 0. |
|
soma_kif_gbar 150.0 [1] |
|
soma_kis_gbar 40.0 [1] |
|
soma_ihpyr_gbar 2.8 [1] |
|
soma_leak_gbar 2.8 [1] |
|
soma_leak_erev -62.0 [1] |
|
soma_e_na 50. [1] |
|
soma_e_k -81.5 [1] |
|
soma_e_h -43.0 [1] |
|
soma_natype napyr |
|
soma_Cap 12 [1] |
|
------------------------------------------------------------------------------------------------------------------------------------------ |
|
|
|
[1] Kanold and Manis, 1999, 2001, 2005 |
|
Age P11-14, Temperature=22C |
|
Units are nS. |
|
[2] Adjustable q10 added for fitting |
|
soma_ihpyr_adj_q10 1.0 [2] (removed for testing) |
|
|
|
""", |
|
) |
|
|
|
add_table_data( |
|
"CW_channels", |
|
row_key="field", |
|
col_key="cell_type", |
|
species="mouse", |
|
data=u""" |
|
|
|
This table describes the ion channel densities and voltage shifts |
|
for a mouse carthweel cell model. |
|
Ad-hoc model, based on a Purkinje cell model (ref [1]). |
|
|
|
|
|
----------------------------------------------------------------------------------------------------------------------------------- |
|
cartwheel |
|
|
|
soma_narsg_gbar 500.0 [1] |
|
soma_bkpkj_gbar 2.0 |
|
soma_kpkj_gbar 100. [1] |
|
soma_kpkj2_gbar 50. |
|
soma_kpkjslow_gbar 150 [1] |
|
soma_kpksk_gbar 25.0 [1] |
|
soma_lkpkj_gbar 5.0 [1] |
|
soma_hpkj_gbar 5.0 [1] |
|
soma_e_na 50. [1] |
|
soma_e_k -80.0 [1] |
|
soma_hpkj_eh -43.0 [1] |
|
soma_lkpkj_e -65.0 [1] |
|
soma_e_ca 50. |
|
soma_na_type narsg |
|
soma_pcabar 0.00015 [1] |
|
soma_Dia 18 |
|
|
|
----------------------------------------------------------------------------------------------------------------------------------- |
|
|
|
[1] Channels from Khaliq, Gouwens and Raman, J. Neurosci. 2003 |
|
Conductance levels modified. |
|
|
|
""", |
|
) |
|
|
|
add_table_data( |
|
"TV_channels", |
|
row_key="field", |
|
col_key="cell_type", |
|
species="mouse", |
|
data=u""" |
|
|
|
This table describes the ion channel densities and voltage shifts |
|
for a mouse tuberculoventral cell model. |
|
Ad-hoc model, based on the t-stellate cell model, but adjusted |
|
to match the data from Kuo and Trussell. |
|
|
|
----------------------------------------------------------------------------------------------------------------------------------- |
|
TVmouse |
|
|
|
soma_nacncoop_gbar 5800.0 [2] |
|
soma_kht_gbar 400.0 [1] |
|
soma_ihvcn_gbar 2.5 [2] |
|
soma_ka_gbar 65.0 [1] |
|
soma_leak_gbar 4.5 [1] |
|
soma_leak_erev -72.0 [1] |
|
soma_e_na 50. [1] |
|
soma_e_k -81.5 [1] |
|
soma_ihvcn_eh -43.0 [1] |
|
soma_na_type nacncoop [2] |
|
soma_Cap 35 [1] |
|
|
|
----------------------------------------------------------------------------------------------------------------------------------- |
|
|
|
[1] Values obtained from brute force runs and comparision to |
|
FI curve from Kuo, Lu and Trussell, J Neurophysiol. 2012 Aug 15; |
|
108(4): 1186–1198. |
|
|
|
[2] Cooperative sodium channel model, based on (see the mechanisms folder) |
|
concepts and implementation similar to Oz et al. J.Comp. Neurosci. 39: 63, 2015, |
|
and Huang et al., PloSOne 7:e37729, 2012. |
|
|
|
|
|
""", |
|
) |
|
|
|
add_table_data( |
|
"sgc_mouse_channels", |
|
row_key="field", |
|
col_key="cell_type", |
|
species="mouse", |
|
data=u""" |
|
|
|
This table describes the ion channel densities (and voltage shifts if necessary) |
|
for SGC cells, based on |
|
|
|
----------------------------------------------------------------------------------------------------------------------------------- |
|
sgc-a sgc-bm |
|
|
|
sgc_name a bm |
|
soma_na_gbar 350. [2] 350. [2] |
|
soma_kht_gbar 58.0 [1] 58.0 [1] |
|
soma_klt_gbar 80.0 [1] 80.0 [1] |
|
soma_ihap_gbar 3.0 [3] 0.0 [1] |
|
soma_ihap_eh -41.0 [3] -41.0 [3] |
|
soma_ihbm_gbar 0.0 [3] 3.0 [3] |
|
soma_ihbm_eh -41.0 [3] -41.0 [3] |
|
soma_leak_gbar 2.0 [1] 2.0 [1] |
|
soma_leak_erev -65 [1] -65 [1] |
|
soma_na_type jsrna [2] jsrna [2] |
|
soma_Cap 12.0 [1] 12.0 [1] |
|
soma_e_k -84 [1] -84 [1] |
|
soma_e_na 50. [1] 50. [1] |
|
|
|
----------------------------------------------------------------------------------------------------------------------------------- |
|
|
|
[1] Model is based on the mouse bushy cell model (XM13, above), |
|
but with a fast sodium channel from Rothman et al, 1993. and Ih currents |
|
from Liu et al. 2014 |
|
|
|
[2] Sodium channel from Rothman, Young and Manis, J Neurophysiol. 1993 Dec;70(6):2562-83. |
|
|
|
[3] Ih Currents from Liu, Manis, Davis, J Assoc Res Otolaryngol. 2014 Aug;15(4):585-99. |
|
doi: 10.1007/s10162-014-0446-z. Epub 2014 Feb 21. |
|
Age "P10" (cultured SGC cells), Original data temperature=22C. |
|
Units are nS. |
|
|
|
""", |
|
) |
|
|
|
|
|
add_table_data( |
|
"sgc_guineapig_channels", |
|
row_key="field", |
|
col_key="cell_type", |
|
species="guineapig", |
|
data=u""" |
|
|
|
This table describes the ion channel densities (and voltage shifts if necessary) |
|
for a model SGC cell, which is based on a bushy cell with a different Na channel. |
|
|
|
----------------------------------------------------------------------------------------------------------------------------------- |
|
sgc-a sgc-bm |
|
|
|
sgc_name a bm |
|
soma_na_gbar 1000. [2] 1000. [2] |
|
soma_kht_gbar 150.0 [1] 150.0 [1] |
|
soma_klt_gbar 200.0 [1] 200.0 [1] |
|
soma_ihap_gbar 3.0 [3] 0.0 [3] |
|
soma_ihap_eh -41.0 [3] -41.0 [3] |
|
soma_ihbm_gbar 0.0 [3] 3.0 [3] |
|
soma_ihbm_eh -41.0 [3] -41.0 [3] |
|
soma_leak_gbar 2.0 [1] 2.0 [1] |
|
soma_leak_erev -65 [1] -65 [1] |
|
soma_na_type jsrna [2] jsrna [2] |
|
soma_Cap 12.0 [1] 12.0 [1] |
|
soma_e_k -84 [1] -84 [1] |
|
soma_e_na 50. [1] 50. [1] |
|
|
|
----------------------------------------------------------------------------------------------------------------------------------- |
|
|
|
[1] Model is based on the guinea pig bushy cell model (RM03, above), |
|
but with a fast sodium channel from Rothman et al, 1993. and Ih currents |
|
from Liu et al. 2014 |
|
|
|
[2] Sodium channel from Rothman, Young and Manis, J Neurophysiol. 1993 Dec;70(6):2562-83. |
|
|
|
[3] Ih Currents from Liu, Manis, Davis, J Assoc Res Otolaryngol. 2014 Aug;15(4):585-99. |
|
doi: 10.1007/s10162-014-0446-z. Epub 2014 Feb 21. |
|
Age "P10" (cultured SGC cells), Temperature=22C. |
|
Units are nS. |
|
|
|
""", |
|
) |
|
|
|
add_table_data( |
|
"MSO_principal_channels", |
|
row_key="field", |
|
col_key="cell_type", |
|
species="guineapig", |
|
data=u""" |
|
|
|
This table describes the ion channel densities |
|
for a putative MSO principal neuron based on the original Rothman Manis 2003 model for bushy cells. |
|
|
|
----------------------------------------------------------------------------------------------------------------------------------- |
|
MSO-principal |
|
|
|
MSO_name Principal |
|
soma_na_gbar 1000. [1] |
|
soma_kht_gbar 150.0 [1] |
|
soma_klt_gbar 200.0 [1] |
|
soma_ka_gbar 0.0 [1] |
|
soma_ih_gbar 20.0 [1] |
|
soma_leak_gbar 2.0 [1] |
|
soma_leak_erev -65 [1] |
|
soma_na_type nacn [1] |
|
soma_ih_type ihvcn [1] |
|
soma_Cap 12.0 [1] |
|
soma_e_k -84 [1] |
|
soma_e_na 50. [1] |
|
soma_ih_eh -43 [1] |
|
|
|
----------------------------------------------------------------------------------------------------------------------------------- |
|
|
|
[1] This MSO neuron model is basied on Rothman and Manis, 2003 bushy cell, type II |
|
Age "adult", Temperature=22C |
|
Units are nS. |
|
|
|
|
|
""", |
|
)
|
|
|