You can not select more than 25 topics
Topics must start with a letter or number, can include dashes ('-') and can be up to 35 characters long.
51 lines
751 B
51 lines
751 B
2 years ago
|
: Ca diffusion in a Purkinje cell
|
||
|
|
: Created 8/15/02 - nwg
|
||
|
|
|
||
|
|
NEURON {
|
||
|
|
SUFFIX cadiff
|
||
|
|
USEION ca READ ica, cai WRITE cai
|
||
|
|
RANGE ca
|
||
|
|
GLOBAL depth, beta
|
||
|
|
}
|
||
|
|
|
||
|
|
UNITS {
|
||
|
|
(mV) = (millivolt)
|
||
|
|
(mA) = (milliamp)
|
||
|
|
(mM) = (milli/liter)
|
||
|
|
(um) = (micron)
|
||
|
|
}
|
||
|
|
|
||
|
|
CONSTANT {
|
||
|
|
F = 9.6485e4 (coul)
|
||
|
|
}
|
||
|
|
|
||
|
|
PARAMETER {
|
||
|
|
cai (mM)
|
||
|
|
dt (ms)
|
||
|
|
|
||
|
|
depth = 0.1 (um)
|
||
|
|
beta = 1 (/ms)
|
||
|
|
}
|
||
|
|
|
||
|
|
ASSIGNED {
|
||
|
|
ica (mA/cm2)
|
||
|
|
}
|
||
|
|
|
||
|
|
STATE {
|
||
|
|
ca (mM)
|
||
|
|
}
|
||
|
|
|
||
|
|
INITIAL {
|
||
|
|
ca = 0.0001
|
||
|
|
}
|
||
|
|
|
||
|
|
BREAKPOINT {
|
||
|
|
ca = ca + (10000.0) * dt * ( ( -1/(2*F)*ica / (depth)) - (0.0001) * beta * ca )
|
||
|
|
|
||
|
|
if ( ca < 1e-4 ) {: minimum 100 nM Ca
|
||
|
|
ca = 1e-4
|
||
|
|
}
|
||
|
|
|
||
|
|
cai = ca
|
||
|
|
}
|