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73 lines
1.1 KiB
73 lines
1.1 KiB
2 years ago
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TITLE KCNQ potassium channel for GPe neuron
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COMMENT
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modeled by Gunay et al., 2008
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implemented in NEURON by Kitano, 2011
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Threadsafe and unit checking, P.B. Manis, 2014
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ENDCOMMENT
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UNITS {
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(mV) = (millivolt)
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(mA) = (milliamp)
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}
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NEURON {
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THREADSAFE
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SUFFIX kcnq
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USEION k READ ek WRITE ik
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RANGE gbar, gk, iKCNQ
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}
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PARAMETER {
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v (mV)
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dt (ms)
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gbar = 0.001 (mho/cm2)
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iKCNQ = 0.0 (mA/cm2)
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ek (mV)
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theta_m = -61.0 (mV)
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k_m = 19.5 (mV)
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tau_m0 = 6.7 (ms)
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tau_m1 = 100.0 (ms)
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phi_m = -61.0 (mV)
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sigma_m0 = 35.0 (mV)
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sigma_m1 = -25.0 (mV)
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}
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STATE {
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m
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}
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ASSIGNED {
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ik (mA/cm2)
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gk (mho/cm2)
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minf
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taum (ms)
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}
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BREAKPOINT {
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SOLVE states METHOD cnexp
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gk = gbar*m*m*m*m
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ik = gk * (v-ek)
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iKCNQ = ik
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}
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INITIAL {
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settables(v)
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m = minf
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}
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DERIVATIVE states {
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settables(v)
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m' = (minf - m)/taum
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}
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PROCEDURE settables(v (mV)) {
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TABLE minf, taum FROM -100 TO 100 WITH 400
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minf = 1.0 / (1.0 + exp((theta_m - v)/k_m))
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taum = tau_m0 + (tau_m1 - tau_m0)/(exp((phi_m - v)/sigma_m0) + exp((phi_m - v)/sigma_m1))
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}
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