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72 lines
1.1 KiB
72 lines
1.1 KiB
TITLE KCNQ potassium channel for GPe neuron |
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COMMENT |
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modeled by Gunay et al., 2008 |
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implemented in NEURON by Kitano, 2011 |
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Threadsafe and unit checking, P.B. Manis, 2014 |
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ENDCOMMENT |
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UNITS { |
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(mV) = (millivolt) |
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(mA) = (milliamp) |
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} |
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NEURON { |
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THREADSAFE |
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SUFFIX kcnq |
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USEION k READ ek WRITE ik |
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RANGE gbar, gk, iKCNQ |
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} |
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PARAMETER { |
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v (mV) |
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dt (ms) |
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gbar = 0.001 (mho/cm2) |
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iKCNQ = 0.0 (mA/cm2) |
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ek (mV) |
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theta_m = -61.0 (mV) |
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k_m = 19.5 (mV) |
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tau_m0 = 6.7 (ms) |
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tau_m1 = 100.0 (ms) |
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phi_m = -61.0 (mV) |
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sigma_m0 = 35.0 (mV) |
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sigma_m1 = -25.0 (mV) |
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} |
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STATE { |
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m |
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} |
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ASSIGNED { |
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ik (mA/cm2) |
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gk (mho/cm2) |
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minf |
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taum (ms) |
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} |
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BREAKPOINT { |
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SOLVE states METHOD cnexp |
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gk = gbar*m*m*m*m |
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ik = gk * (v-ek) |
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iKCNQ = ik |
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} |
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INITIAL { |
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settables(v) |
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m = minf |
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} |
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DERIVATIVE states { |
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settables(v) |
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m' = (minf - m)/taum |
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} |
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PROCEDURE settables(v (mV)) { |
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TABLE minf, taum FROM -100 TO 100 WITH 400 |
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minf = 1.0 / (1.0 + exp((theta_m - v)/k_m)) |
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taum = tau_m0 + (tau_m1 - tau_m0)/(exp((phi_m - v)/sigma_m0) + exp((phi_m - v)/sigma_m1)) |
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}
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