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93 lines
2.0 KiB
93 lines
2.0 KiB
2 years ago
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TITLE kdpyr.mod DCN pyramidal cell model, delayed rectifier
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COMMENT
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This is part of a model implements a Dorsal Cochlear Nucleus Pyramidal point cell
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based on kinetic data from Kanold and Manis (1999) and Kanold's dissertation (1999)
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-- 15 Jan 1999 P. Manis
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Added export of start states for some variables to do perturbation tests
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These start values replace the "inf" values used in the initialization procedure
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Note that if the start variable is set to a value less than 0,
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then the default initialization will be done. Typically I use a value of -1 for this flagging
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Note also that it is possible to set the initial values > 1 but this is meaningless in terms of
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the present equations.
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-- 5 Feb 1999 P. Manis
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ENDCOMMENT
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UNITS {
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(mA) = (milliamp)
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(mV) = (millivolt)
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}
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NEURON {
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THREADSAFE
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SUFFIX kdpyr
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USEION k READ ek WRITE ik
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RANGE gbar, gk : delayed rectifier
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RANGE ntau: time constants delayed rectifier
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RANGE kd_avh
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}
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INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
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PARAMETER {
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v (mV)
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celsius (degC)
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dt (ms)
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ek (mV) : = -81.5 (mV)
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gbar = 0.006667 (mho/cm2) <0,1e9>
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ntau = 0.5 (ms) <0.1,100>
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kd_avh = -40 (mV)
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}
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STATE {
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n
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}
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ASSIGNED {
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gk (mho/cm2)
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ik (mA/cm2)
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ninf
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}
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LOCAL nexp
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BREAKPOINT {
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SOLVE states METHOD cnexp
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gk = gbar*n*n
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ik = gk*(v - ek)
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}
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INITIAL {
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rates(v)
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n = ninf
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}
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DERIVATIVE states {
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rates(v)
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n' = (ninf - n) / ntau
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}
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LOCAL q10
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PROCEDURE rates(v(mV)) { :Computes rate and other constants at current v.
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:Call once from HOC to initialize inf at resting v.
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LOCAL alpha, beta, sum
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TABLE ninf, ntau DEPEND celsius FROM -200 TO 100 WITH 400
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q10 = 3^((celsius - 22)/10 (degC))
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: "n" potassium activation system
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ninf = kd_m(v)
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}
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: Make these as functions so we can view them from hoc, although this
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: may slow things down a bit
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FUNCTION kd_m(x (mV)) { : potassium activation
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kd_m = 1/(1+exp(-(x-kd_avh)/(3 (mV)))) : flat time constants
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}
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